New preprint on combining tetrodes with silicon probes in freely moving mice

Ever wanted to combine tetrodes with silicon probes to simultaneously measure neural activity from within and across neural layers in a freely moving mouse? A new preprint (together with the Battagla lab) describing a small device to do this is now on bioRxiv:

Guardamagna M, Eichler R, Pedrosa R, Aarts A, Meyer AF*, Battaglia FP*. The Hybrid Drive: a chronic implant device combining tetrode arrays with silicon probes for layer-resolved ensemble electrophysiology in freely moving mice) bioRxiv, 2021.

We extensively validated the drive and demonstrated its power in a series of experiments linking the spiking activity of CA1 pyramidal layer neurons to the oscillatory activity across hippocampal layers.